The Helminthoglyptinae are a subfamily of air-breathing land snails, terrestrial pulmonate gastropod mollusks within the family Xanthonychidae. This is a large and diverse group of new world snails, ranging in distribution from Alaska through North America to the West Indies, Central America, and as far south as Argentina.

The shells are typically of medium to large size, with no apertural teeth but usually with a reflected apertural lip. In the species in this family, the diverticulum may be present or absent. They possess a single dart apparatus with one stylophore (dart sac) and two mucus glands. These snails use the love dart as part of their mating behavior. In this subfamily, the number of haploid chromosomes lies between 26 and 30 (according to the values in this table).